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Join us in a celebration of science that brings together fit for purpose neuroscience solutions from Bruker Spatial Biology platforms.
Discovering Novel Biomarkers: Learn about new biomarkers for cerebral small vessel disease (cSVD) and their role in diagnosing dementia with the nCounter® Analysis Platform.
Exploring Microglial Function: Hear about the mapping of microglial morphology and function in ischemic stroke recovery with the CosMx® Neuroscience Protein Panel.
Integrating Multiomic Data: Gain insights into high-plex single-cell spatial molecular imaging with CosMx SMI for comprehensive neural analysis.
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With the rapidly expanding aging population, and the incidence of dementia expected to grow with this population, developing sensitive and accessible biomarkers that reveal the pathophysiology occurring in the brain is imperative. Currently, the two leading causes of dementia, Alzheimer’s disease (AD) and vascular contributions to cognitive impairment and dementia (VCID), are best diagnosed clinically with either costly PET or MRI scans and relatively nonspecific neuropsychological evaluations. Since some of these methods lack sensitivity and specificity, there is a clear need to develop novel biomarkers and understand how said biomarkers reflect underlying disease mechanisms. While rapidly emerging plasma biomarkers are gaining traction and specificity for AD, there is a lack of markers for VCID, in particular cerebral small vessel disease (cSVD), the most common VCID pathology.The retina has become a promising biomarker for AD and VCID, but the specific mechanisms underlying retinal changes that reflect brain disease are unclear. |
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Using our model of hyperhomocysteinemia (HHcy)-induced cSVD, we aimed to identify the effects of cSVD on visual sensitivity and cognition, retinal glial and vascular cells, and neuroinflammatory and cardiovascular gene expression changes. Ultimately, HHcy led to visual deficits that specifically affected the reaction to blue and white light, decreased vascular volume and decreased interaction of microglia with the vasculature, as well as the downregulation of inflammatory and vascular genes. These changes provide novel insights and reproduce some prior observations. These studies highlight retinal changes in association with cSVD and serve as a precaution when interpreting vision-dependent cognitive testing of cSVD models. |
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Bridget Ashford Post Doctoral Research Associate University of Sheffield |